The risk factors for severe reactions to andrographis are unknown.
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Adverse reports data suggests subsequent reactions may be more severe. However, in some cases the first reported reaction was severe, even when a product was previously used without incident.
In advice published last week, the regulator advised against the use of the supplements in people with a history of severe allergic reactions to any trigger.
“[They] should be cautious using a medicine containing andrographis and stop using it at the first sign of any allergic reaction,” it advised.
Royal Australian College of GPs chair Dr Lara Roeske said winter viruses meant more people were using immunity supplements.
“It is a really timely reminder to read the label and let your health practitioner know if you do have allergies,” she said, noting people with existing allergies were typically at higher risk of having a reaction to a new substance.
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“These symptoms will be much more severe than typical cold and flu symptoms, and symptoms of hypersensitivity happen pretty soon after you’ve ingested the medication,” she added.
Dr Ian Musgrave, a pharmicology researcher at the University of Adelaide, said there was a limited understanding of adverse events to alternative medicines because, although some have been used for centuries, reactions may not have been linked to the ingredient. People also may not report using these products to a medical practitioner, he said.
While such reactions are rare, Musgrave said the public needed to realise that “low” risk is not “no” risk, and carefully read warnings.
“People may not necessarily read the warnings, as they believe that ‘natural’ medicines have no side effects,” he said.
“The tragic death is a wake-call for people to be more aware that herbal and alternative medicines have the potential for harm.”
A spokesperson for Blackmores, Bioceuticals’ parent company, said it took adverse events seriously and all of its products complied with TGA regulations.
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