The scans can open a whole new front in the treatment of kidney patients. We expect to use them to tailor treatment to the individual patient when we can identify patients who need rapid and targeted treatment
Nikolaj Bøgh
The technology works by injecting a special form of pyruvate, a natural substance in the body’s energy production, into the patient’s body. When pyruvate molecules are hyperpolarized, their magnetic signals are significantly amplified, more than 20,000 times. This allows tracking their conversion in the body using an MRI scanner. By tracking how pyruvate converts into other substances, doctors can detect early signs of fibrosis before there are visible structural changes that can be captured with standard methods.
The method is not only more effective but also safer and more comfortable for patients, as it eliminates the need for invasive biopsies. “The scans can open a whole new front in the treatment of kidney patients. We expect to use them to tailor treatment to the individual patient when we can identify patients who need rapid and targeted treatment,” explains Nikolaj Bøgh.
The technology has the potential to be applied in other areas beyond kidney diseases. Fibrogenesis, which the technology measures, is not unique to the kidneys but can also be relevant to other organs, such as the heart in certain types of heart failure. However, to transfer the technology from the laboratory to the clinic, further trials on patients are required.
Nikolaj Bøgh and his colleagues have already initiated three clinical studies on patients with various kidney diseases. The studies aim to demonstrate the method’s value, including in identifying diabetic patients at high risk of developing kidney disease. Although the technology shows great potential, it will be challenging to implement it widely in clinical practice. There are only about 24 of these advanced scanners in the world, and even fewer can examine humans with the technology. Over the coming years, however, researchers hope to see the technology become more accessible and widespread. “We hope to see the technology become more available so that patients can benefit from a scanner that is more than 20,000 times more sensitive than the conventional scanners we use in hospitals today,” says Nikolaj Bøgh.
Source: Aarhus University