Quinton de Kock is on prime form as South Africa bat first against USA in the Super Eights, firing his side to 64/1 after eight overs.
The USA were the story of the opening round, stunning the cricket world to progress from Group A along with India at the expense of Pakistan, Canada and Ireland.
The co-hosts produced the shock of the tournament when they beat Pakistan in New York, and will be looking to take another major scalp at the Sir Vivian Richards Stadium in Antigua.
South Africa won all four of their fixtures in Group D to progress to the Super Eight stage, but were pushed close in a number of those matches and will be looking for a confidence-building statement against the lowest-ranked team in this stage of the tournament.
Scorecard: USA v South Africa
Toss: USA win toss and will bowl first