Collingwood has had to make five changes as the club deals with an injury list 16 players long.
Veterans Scott Pendlebury, Mason Cox and Brody Mihocek will all miss, though Jeremy Howe returns.
The Bulldogs have been hit hard as well with a trio of injuries, including Ed Richards and Aaron Naughton.
West Coast trade recruit Matt Flynn will make his debut for the club and Andrew Gaff has finally returned to the side after a lengthy stint in the WAFL.
More big outs at Richmond, with Shai Bolton injured and Dion Prestia managed.
See all the changes below.
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Port Adelaide versus Carlton
Port Adelaide
IN: C. Dixon, F. Evans, I. Soldo
OUT: W. Rioli, J. Sweet, C. Rozee
Carlton
UNCHANGED
Collingwood versus Western Bulldogs
Collingwood
IN: O.Markov, J.Bytel, A.Johnson, J.Howe, F.Macrae
OUT: E.Allan (Omitted), S.Pendlebury (Injured), B.Mihocek (Injured), J.Richards (Injured), M.Cox (Injured)
Western Bulldogs
IN: J.O’Donnell, R.Lobb, L.McNeil
OUT: A.Scott (Injured), A.Naughton (Injured), E.Richards (Injured)
Hawthorn versus Adelaide
Hawthorn
IN: N. Reeves
OUT: L.Meek (Injured)
Adelaide
UNCHANGED
West Coast versus St Kilda
West Coast
IN: H.Edwards, M.Flynn, A.Gaff, J.Petruccelle
OUT: J.Rotham (Illness), J.Hunt (Injured), T.Dewar (Omitted), J.Williams (Omitted)
St Kilda
IN: T.Membrey, H.Clark, D.Butler
OUT: L.Stocker (Injured), C.Sharman (Omitted), L.Collard (Omitted)
Geelong versus Richmond
Geelong
IN: G.Rohan, M.O’Connor
OUT: M.Blicavs (Suspension), J.Clark (Suspension)
Richmond
IN: R.Mansell, J.Graham, K.Smith
OUT: S.Bolton (Injured), D.Prestia (Managed), S.Green (Omitted)
Melbourne versus Fremantle
Melbourne
IN: D.Turner
OUT: J.van Rooyen (Injured)
Fremantle
IN: M.Frederick, S.Sturt
OUT: M.Johnson (Managed), T.Emmett (Omitted)
Gold Coast versus Essendon
Gold Coast
IN: S.Flanders, N.Moyle, W.Graham
OUT: J. Rogers (Omitted), J.Witts (Injured), A.Davies (Omitted)
Essendon
IN: H.Jones, J.Menzie
OUT: N. Caddy (Illness), A.Davey Jnr (Omitted)